This paper examines emerging trends in biotechnology and the role of engineering solutions in addressing challenges related to human health, environmental sustainability, and industrial applications. Drawing on interdisciplinary research from biotechnology, bioengineering, and environmental science, the paper explores recent advancements in biotechnological tools, techniques, and applications. It discusses how engineering principles are applied in areas such as genetic engineering, synthetic biology, bioprocessing, and bioremediation to develop novel solutions for healthcare, agriculture, energy production, and environmental protection. Through a comprehensive review of empirical studies and case examples, the paper highlights the potential of biotechnology to revolutionize medical treatments, enhance crop productivity, produce renewable fuels, and mitigate environmental pollution. Additionally, the paper addresses ethical, regulatory, and societal considerations associated with the use of biotechnological innovations, including concerns related to biosafety, biosecurity, and genetic privacy. Through case studies and examples of successful biotechnology applications, the paper illustrates the transformative impact of engineering-driven biotechnological advancements on human well-being and planetary sustainability. The paper concludes by discussing future directions and challenges in biotechnology research and deployment, emphasizing the need for interdisciplinary collaboration, responsible innovation, and stakeholder engagement to realize the full potential of biotechnology for the benefit of society and the environment.